Hyposmia Is Associated with RBD for PD Patients with Variants of SNCA

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Hyposmia Is Associated with RBD for PD Patients with Variants of SNCA

Objective: Hyposmia may occur simultaneously with REM sleep behavior disorder (RBD) as a specific phenotype in Parkinson's Diseases (PD), of which the disease progression is fast. In the study, we tried to identify whether the genotypic characteristics could participate in the co-occurrence of hyposmia and RBD in PD patients. Methods: 152 PD patients were recruited from the Department of Neurol...

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Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy

BACKGROUND Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by parkinsonism, cerebellar ataxia and autonomic dysfunction. Pathogenic mechanisms remain obscure but the neuropathological hallmark is the presence of alpha-synuclein-immunoreactive glial cytoplasmic inclusions. Genetic variants of the alpha-synuclein gene, SNCA, are thus strong candidates for g...

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ژورنال

عنوان ژورنال: Frontiers in Aging Neuroscience

سال: 2017

ISSN: 1663-4365

DOI: 10.3389/fnagi.2017.00303